ADRENOCEPTOR CLASSIFICATION, Clinical and Experimental.
Because sympathetic activity can precipitate arrhythmias, drugs that block beta 1-adrenoceptors are used to inhibit sympathetic effects on the heart. Because beta-adrenoceptors are coupled to ion channels through defined signal transduction pathways, beta-blockers indirectly alter membrane ion conductance, particularly calcium and potassium conductance.
The relationship between alpha-adrenoceptor occupancy and vasoconstrictor response is more favorable for postsynaptic vascular alpha 1 adrenoceptors than for alpha 2 adrenoceptors in both arteries.
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Studies of the functional interactions of the DSV and the DMV with WB 4101 or 5-methylurapidil (5-MU) suggested the presence of alpha 1D-adrenoceptors in the DSV and alpha 1A-adrenoceptors in the DMV.
THERE is much evidence to suggest that beta adrenoceptors are not homogeneous-pharmacological data on the actions of beta adrenoceptor agonists and antagonists in intact tissues indicate the.
Adrenoceptors mediating relaxant responses to exogenously added or endogenously released catecholamines in isolated canine bronchi (3rd-6th order) were characterized using selective beta receptor agonists and antagonists. Norepinephrine (3 x 10(7) to 3 x 10(-5) M) or isoproterenol (3 x 10(-8) to 10(-6) M) fully relaxed tissues precontracted with 3 x 10(-7) M carbachol (Cch).
Adrenoceptors play a significant role in adrenergic-mediated contractile responses in the bovine tail vein via activation of both aiA- and ais-adrenoceptors, but not via aio- adrenoceptors.